RUNX1 isoform disequilibrium in the development of trisomy 21 associated myeloid leukemia
S. Gialesaki, D. Brauer-Hartmann, R. Bhayadia, O. Alejo-Valle, H. Issa, E. Regenyi, C. Beyer, M. Labuhn, C. Ihling, A. Sinz, M. Glass, S. Huttelmaier, S. Matzk, L. Schmid, F. J. Struwe, , J.-H. Klusmann
This study identifies RUNX1 isoform imbalance as a key driver of trisomy 21-associated myeloid leukemia and shows that restoring this balance can reverse leukemogenesis.
bioRxiv · Mar 7, 2022 · PreprintCancer Biology