Author

C. Ihling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:genetic perturbation / CRISPR· 3 Assay:multiome· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. Sinz· 8 shared E. Wahle· 3 shared C. Beyer· 2 shared C. Tueting· 2 shared D. Heckl· 2 shared D. Reinhardt· 2 shared E. Regenyi· 2 shared H. Issa· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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8 shared papersBiochemistry

A. Sinz

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

L. Schmidt, C. Tueting, F. L. Kyrilis, F. Hamdi, D. A. Semchonok, G. Hause, A. Meister, C. Ihling, P. N. Shah, M. T. Stubbs, A. Sinz, D. I. Stuart, P. L. Kastritis

The paper uses cryo-EM and computational analysis to study the structure and organization of the yeast L-A virus in native cell extracts, revealing capsid architecture and viral community dynamics.

bioRxiv · Jul 15, 2022Biochemistry

RUNX1 isoform disequilibrium in the development of trisomy 21 associated myeloid leukemia

S. Gialesaki, D. Brauer-Hartmann, R. Bhayadia, O. Alejo-Valle, H. Issa, E. Regenyi, C. Beyer, M. Labuhn, C. Ihling, A. Sinz, M. Glass, S. Huttelmaier, S. Matzk, L. Schmid, F. J. Struwe, , J.-H. Klusmann

This study identifies RUNX1 isoform imbalance as a key driver of trisomy 21-associated myeloid leukemia and shows that restoring this balance can reverse leukemogenesis.

bioRxiv · Mar 7, 2022 · PreprintCancer Biology

Reconstitution of 3'-processing of mammalian pre-mRNA reveals a central role of RBBP6

M. Schmidt, F. Kluge, F. Sandmeir, U. Kühn, P. Schäfer, C. Tüting, C. Ihling, E. Conti, E. Wahle

The paper reconstitutes the 3'-processing of mammalian pre-mRNA and identifies essential and stimulatory proteins, highlighting RBBP6's role in activating CPSF73.

bioRxiv · Nov 2, 2021 · PreprintBiochemistry

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

O. Alejo-Valle, K. Weigert, R. Bhayadia, M. Ng, S. Emmrich, C. Beyer, K. Schuschel, C. Ihling, A. Sinz, M. Flasinski, H. Issa, E. Regenyi, M. Labuhn, D. Reinhardt, M.-L. Yaspo, , J.-H. Klusmann

This paper identifies ARID3A repression by miR-125b as a key driver of megakaryoblastic leukemia, showing that restoring ARID3A expression can reverse differentiation arrest in AMKL.

bioRxiv · Apr 26, 2021Cancer Biology

High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

N. Braun, S. Friis, C. Ihling, A. Sinz, J. Andersen, S. A. Pless

The paper develops a high-throughput method to study functional and pharmacological properties of ncAA-containing hASIC1a variants using automated patch-clamp.

bioRxiv · Nov 24, 2020Biophysics

IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer

N. Bley, A. Schott, S. Mueller, D. Misiak, M. Lederer, T. Fuchs, C. Assmann, M. Glass, C. Ihling, A. Sinz, N. Pazaitis, C. Wickenhauser, M. Vetter, O. Ungurs, H.-G. Strauss, , S. Huettelmaier

This study identifies IGF2BP1 as a driver of invasive growth in ovarian cancer through SRC/MAPK signaling, showing that combinatorial SRC/MEK inhibition is effective in treating mesenchymal-like HG-SOC.

bioRxiv · Jun 19, 2020Cancer Biology

Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients

C. Ihling, D. Taenzler, S. Hagemann, A. Kehlen, S. Huettelmaier, A. Sinz

The paper develops an MS-based method to detect SARS-CoV-2 proteins in gargle samples from COVID-19 patients using acetone precipitation and targeted MS analysis.

bioRxiv · Apr 18, 2020Biochemistry

Reconstitution of mammalian Cleavage Factor II involved in 3’ processing of mRNA precursors

P. Schaefer, C. Tueting, L. Schoenemann, U. Kuehn, T. Treiber, N. Treiber, C. Ihling, A. Graber, W. Keller, G. Meister, A. Sinz, E. Wahle

This study reconstitutes mammalian Cleavage Factor II as a heterodimer of hPcf11 and hClp1, showing its activity in RNA cleavage and RNA binding preferences.

bioRxiv · Aug 16, 2018Biochemistry

Translational Repression Of The Drosophila nanos mRNA Involves The RNA Helicase Belle And RNA Coating By Me31B And Trailer hitch

M. Gotze, J. Dufourt, C. Ihling, C. Rammelt, S. Pierson, N. Sambrani, C. Temme, A. Sinz, M. Simonelig, E. Wahle

The paper identifies Belle as a novel component of the SRE-dependent repressor complex that contributes to translational repression of nanos mRNA in Drosophila.

bioRxiv · May 24, 2017Biochemistry