A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes
L. E. Heasley, L. Schubert, A. T. Le, T. K. Hinz, A. Navarro, S. K. Nelson-Taylor, R. A. Nemenoff, R. C. Doebele
This paper describes a method to validate sgRNAs that generate RET and NTRK1 fusion oncogenes in murine models, demonstrating their efficacy in creating tumor models responsive to targeted therapies.
bioRxiv · Apr 6, 2023 · PreprintCancer Biology