A. Navarro

Inflammation promotes aging-associated oncogenesis in the lung.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.

The HSFA1a is stabilized by the co-chaperone HSP70-HSP90 organizing protein HOP in Arabidopsis

This study shows that HOP stabilizes HSFA1a in Arabidopsis, which is required for the heat stress response during thermomorphogenesis.

The distribution of global tidal marshes from earth observation data

This paper creates a high-resolution global map of tidal marshes in 2020 using earth observation data and a random forest model, estimating their extent and distribution.

A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes

This paper describes a method to validate sgRNAs that generate RET and NTRK1 fusion oncogenes in murine models, demonstrating their efficacy in creating tumor models responsive to targeted therapies.

Novel EGFR-Mutant Mouse Models of Lung Adenocarcinoma Reveal Adaptive Immunity Requirement for Durable Osimertinib Response

Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer

This paper shows that adaptive immunity enhances the durability of alectinib response in EML4-ALK lung cancer models, with CD8+ T cells playing a key role.

Whole-genomes from the extinct Xerces Blue butterfly can help identify declining insect species

The paper sequenced genomes of extinct and historical Xerces Blue butterflies and their relatives to study population decline and identify genetic markers for threatened species.

Assessing the role of inversions in maintaining genomic differentiation after secondary contact: local adaptation, genetic incompatibilities, and drift

This study shows that chromosomal inversions can maintain genomic differentiation after secondary contact in finite populations, even with gene flux, by prolonging differentiation persistence and allowing for new incompatibilities and adaptations.

Evolutionary phenome-genome analysis of cranial suture closure in mammals

This study identifies brain size and skull ossification order as key factors for suture patency in mammals and discovers three novel genes linked to suture closure.

Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

The paper profiles epigenomic features in primate LCLs to reveal evolutionary patterns of epigenetic activity in gene regulation.

Mutation distribution density in tumors reconstructs human’s lost diversity

The paper compares mutation density patterns between human and non-human Great Ape germlines and tumors, finding that non-human germlines better correlate with tumors than human germlines.