A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes
L. E. Heasley, L. Schubert, A. T. Le…·R. C. Doebele
This paper describes a method to validate sgRNAs that generate RET and NTRK1 fusion oncogenes in murine models, demonstrating their efficacy in creating tumor models responsive to targeted therapies.