A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
T. M. Grubb, S. Maganti, J. M. Krill-Burger, C. Fraser, L. Stransky, T. Radivoyevitch, K. Sarosiek, F. Vazquez, W. G. Kaelin, A. Chakraborty
The paper identifies a mesenchymal tumor cell state that increases dependency on BCL-XL in kidney cancer, showing anti-tumor efficacy of a BCL-XL inhibitor.
bioRxiv · Jan 29, 2022 · PreprintCancer Biology