K. Sarosiek

This study shows high-intensity ultrasound increases anti-inflammatory EV secretion from skeletal myotubes by raising intracellular calcium levels, which reduces pro-inflammatory gene expression in macrophages.

This study uses cryo-electron tomography to visualize how different Opa1 forms affect mitochondrial cristae architecture and function in mouse cells.

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

The paper identifies new BAK binders that show similar binding modes and kinetics to both activators and inhibitors, suggesting sequence-function relationships are not determined by affinity or kinetics.

The paper identifies a mesenchymal tumor cell state that increases dependency on BCL-XL in kidney cancer, showing anti-tumor efficacy of a BCL-XL inhibitor.

This study identifies that clonal plasma cells in AL amyloidosis depend on BCL-2 family proteins and are sensitive to BH3 mimetics, suggesting potential therapeutic strategies.