C. Fraser

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

The paper identifies a mesenchymal tumor cell state that increases dependency on BCL-XL in kidney cancer, showing anti-tumor efficacy of a BCL-XL inhibitor.

Epidemiological dynamics of bacteriocin competition and antibiotic resistance

This study examines bacteriocin dynamics and their link to antibiotic resistance in epidemiological models, finding that diversity can be maintained through competition-colonisation trade-offs rather than rock-paper-scissors dynamics.

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

The paper examines age-related changes in ACE2 expression and apoptosis regulation in lung tissue, linking these to differences in COVID-19 severity across age groups.

Predicting evolution using frequency-dependent selection in bacterial populations

The paper predicts changes in pneumococcal populations after vaccination by analyzing accessory gene frequencies under negative frequency-dependent selection.

Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae

The study examines antibiotic resistance frequencies in Streptococcus pneumoniae and finds that horizontal gene transfer rates are not the main factor influencing these frequencies.

Clonal plasma cells in AL amyloidosis are dependent on pro survival BCL-2 family proteins and sensitive to BH3 mimetics

This study identifies that clonal plasma cells in AL amyloidosis depend on BCL-2 family proteins and are sensitive to BH3 mimetics, suggesting potential therapeutic strategies.

On the evolutionary ecology of multidrug resistance in bacteria

This paper explains high multidrug resistance frequencies in bacteria through ecological models of strain competition, showing that resistance to different antibiotics often co-occurs due to stable coexistence rather than competitive exclusion.

PHYLOSCANNER: Inferring Transmission from Within- and Between-Host Pathogen Genetic Diversity

PHYLOSCANNER infers transmission direction and identifies multiply infected individuals from pathogen genetic diversity across hosts using sequence data.

Host population structure and treatment frequency maintain balancing selection on drug resistance

The paper models how host population structure and treatment frequency influence the coexistence of drug-sensitive and resistant strains of Streptococcus pneumoniae.