Cancer BiologybioRxiv
Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth.
M. K. Penny, A. M. Lerario, K. J. Basham…·G. D. Hammer
This paper identifies a Wnt/β-catenin-regulated extracellular matrix (ECM) program in adrenocortical carcinoma (ACC) that promotes tumor growth and shows that inhibiting this pathway reduces tumor viability and growth in preclinical models.
DOI 10.3390/cancers15143559