Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis
J. Tschuck, L. Theilacker, I. Rothenaigner, S. A. Weiss, B. Akdogan, C. Mueller, R. Graf, S. Brandner, C. Puetz, T. Rieder, P. Schmitt-Kopplin, H. Zischka, K. Schorpp, K. Hadian
This study identifies FXR agonists that suppress ferroptosis by upregulating protective proteins, highlighting FXR's role in preventing lipid peroxidation and ferroptotic cell death.
bioRxiv · Oct 7, 2022 · PreprintCell Biology