C. Mueller

Comparison of the tolerability of 161Tb- and 177Lu-labeled somatostatin analogues in the preclinical setting

This study compares the tolerability of 161Tb- and 177Lu-labeled somatostatin analogues in mice, finding that SSTR antagonists caused more hematologic changes than agonists, but both were safe at therapeutic activity levels.

Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

Impact of genomic background and developmental state on signaling pathways and response to therapy in Glioblastoma patient-derived cells

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus

This study identifies eburicol accumulation as the mechanism by which azoles exert fungicidal effects against Aspergillus fumigatus, distinct from their action in yeasts.

Flower visitor groups show differential responses to individual and plot-level chemodiversity with consequences for plant fitness

This study examines how individual and plot-level chemodiversity affects pollinator and florivore visits and plant fitness in Tanacetum vulgare.

Bioprocess optimization enables enhanced protopanaxadiol production in yeast

This study optimizes bioprocess conditions to enhance protopanaxadiol production in yeast using Design of Experiment, achieving a 7.5-fold increase in yield.

Chemodiversity in flowers of Tanacetum vulgare has consequences on a florivorous beetle

This study shows that different chemotypes of Tanacetum vulgare, defined by leaf terpenoids, also have distinct floral and pollen chemotypes that influence beetle preference and performance.

Selective effects of estradiol on human corneal endothelial cells

This study investigates how estradiol affects human corneal endothelial cells under different oxygen conditions, finding sex-specific effects on mitochondrial morphology and ATP levels.

Inter-laboratory comparison of plant volatile analyses in the light of intra-specific chemodiversity

This study assesses the reproducibility of plant volatile organic compound (VOC) analysis across five laboratories using Tanacetum vulgare, finding high variation in VOC profiles and JA-induced changes.

Intraspecific chemodiversity provides plant individual- and neighbourhood-mediated associational resistance towards aphids

This study investigates how plant chemodiversity at individual and neighbourhood levels affects aphid abundance and attraction, finding specific effects depending on chemotype and aphid species.

Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis

This study identifies FXR agonists that suppress ferroptosis by upregulating protective proteins, highlighting FXR's role in preventing lipid peroxidation and ferroptotic cell death.

Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency

A small molecule screen in patient iPSCs with in vivo validation in mice identifies LRRK2 as a new therapeutic target for Alpha-1 Antitrypsin Deficiency.

bletl - A Python package for integrating microbioreactors in the design-build-test-learn cycle

The paper introduces the bletl Python package for analyzing microbioreactor data, enabling machine learning and robust data analysis through automated preprocessing and specialized functions.

Intergenerational Effects of Early Life Starvation on Life-History, Consumption, and Transcriptome of a Holometabolous Insect

The paper investigates intergenerational effects of parental larval starvation on offspring traits and gene expression in Athalia rosae, finding trait-dependent effects and gene-level changes.

Fighting over defence chemicals disrupts mating behaviour

This study shows that fighting over chemical defenses disrupts mating behavior in turnip sawflies, with aggression levels dependent on body mass differences between sexes.

Consequences of pharmacophagous uptake from plants and conspecifics in a sawfly elucidated using chemical and molecular techniques

The paper investigates pharmacophagy in the turnip sawfly, showing that conspecific nibbling transfers clerodanoids and upregulates metabolic pathways, despite metabolic costs.

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α

This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.

CD8+ T cell priming in oral mucosa-draining lymph nodes supports systemic immunity

This study shows that CD8+ T cells are primed in mandibular lymph nodes after oral Listeria monocytogenes infection, contributing to systemic immunity.

In cell architecture of the nuclear pore complex and snapshots of its turnover

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

Inhibiting coronavirus replication in cultured cells by chemical ER stress

This study shows that thapsigargin inhibits coronavirus replication by modulating ER stress and quality control pathways in cultured cells.

Chemical patterns of colony membership and mother-offspring similarity in Antarctic fur seals are reproducible over time

The paper replicates a previous study on Antarctic fur seals, confirming that colony membership and mother-offspring chemical similarity are reproducible over time and across colonies.

Rapid and independent evolution of ancestral and novel defenses in a genus of toxic plants (Erysimum, Brassicaceae)

The paper examines the evolution of chemical defenses in Erysimum plants, finding that ancestral and novel defenses evolved independently without trade-offs.

Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB

This study investigates the interaction between FtsQ and FtsB in E. coli, revealing key residues and structural details critical for cell division.

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality

The paper identifies genes under positive selection in long-lived rodents, linking them to mTOR-related processes, immune function, and antioxidant defense, and finds expression patterns consistent with antagonistic pleiotropy in aging.

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.