Author

L. Tomaszek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. P. Adam· 2 shared N. Martino· 2 shared R. Bossardi Ramos· 2 shared A. Jaitovich· 1 shared D. Chuy· 1 shared G. Fredman· 1 shared K. Leyden· 1 shared P. A. Vincent· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

A. P. Adam

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2 papers

Recent·Most cited

SOCS3 limits endotoxin-induced endothelial dysfunction by blocking a required autocrine interleukin 6 signal in human umbilical vein endothelial cells

N. Martino, R. Bossardi Ramos, D. Chuy, L. Tomaszek, A. P. Adam

The paper shows that sIL-6R enhances LPS-induced endothelial dysfunction by activating STAT1/STAT3, which is blocked by SOCS3 overexpression or JAK inhibition.

bioRxiv · Apr 25, 2022 · PreprintCell Biology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology