S. Lu

IgM plays a prominent role in naturally acquired immunity against Plasmodium falciparum gametocytes

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.

The effect of circulating neutralizing antibodies on the replication of SARS-CoV-2 variants following post-vaccination infections.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

KLF4 in smooth muscle cell-derived progenitor cells is essential for angiotensin II-induced cardiac inflammation and fibrosis

This study shows that KLF4 in smooth muscle cell-derived progenitor cells drives AngII-induced cardiac inflammation and fibrosis by promoting a profibrotic phenotype.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis

This study designs and synthesizes functional fluorophores using a scaffold-based Ugi reaction, enabling detection of reactive-oxygen species and controlled subcellular localization, with some compounds showing pyroptosis-inducing activity in cancer cells.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

Visualization of endogenous G proteins on endosomes and other organelles

The paper visualizes endogenous G proteins on endosomes and other organelles using gene editing and microscopy, showing their distribution and trafficking.

PHOSPHATE-INDUCED 1 and its paralogs positively regulate cellulose biosynthesis in Arabidopsis.

This study shows that PHOSPHATE-INDUCED 1 and its paralogs regulate cellulose biosynthesis in Arabidopsis by modulating CSC activity in response to developmental and environmental cues.

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

KatG catalase deficiency confers bedaquiline hyper-susceptibility to isoniazid resistant Mycobacterium tuberculosis

This study identifies KatG catalase deficiency in INH-resistant M. tuberculosis as a factor contributing to hyper-susceptibility to bedaquiline.

Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner

This study shows that Klf4-dependent transitions in adventitial progenitor cells affect plaque stability in atherosclerosis by altering fibroblast, SMC, and macrophage phenotypes.

Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum

This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer

This study shows that elraglusib enhances immune cell activation and synergizes with anti-PD-L1 in a murine colorectal cancer model, with clinical implications for combination immunotherapy.

The TNF{blacktriangleup}ARE mouse as a model of intestinal fibrosis

The paper evaluates the TNF{Delta}ARE mouse as a model of intestinal fibrosis, finding it develops structural, histological, and genetic changes of ileal fibrosis by 24 weeks.

A stable reference human transcriptome and proteome as a standard for reproducible omics experiments

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

Shock drives a highly coordinated transcriptional and DNA methylation response in the endothelium

The paper investigates how shock-induced IL-6 signaling alters DNA methylation and transcription in endothelial cells, revealing a mechanism for sustained vascular dysfunction post-shock.

Nucleotide-decoupled G proteins reveal the role of G protein conformation in receptor-G protein selectivity

This study investigates GPCR-G protein selectivity by using nucleotide-decoupled G protein variants, finding that selectivity decreases when nucleotide release is not required for complex formation.

Mechanosensor Piezo1 Mediates Bimodal Patterns of Intracellular Signaling

This study reveals a bimodal pattern of Piezo1-mediated intracellular calcium and FAK signaling, dependent on the degree of Piezo1 activation.

Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation.

This study identifies elevated fungal translocation markers in PASC patients, which induce NF-κB inflammation through Dectin-1 signaling.

Sympathetic blockage attenuates fasting-induced hepatic steatosis

This study shows that blocking the sympathetic nervous system reduces fasting-induced liver fat accumulation by suppressing CD36 upregulation.

Orchestration of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plant

This study identifies ORANGE family proteins as regulators of chlorophyll and carotenoid biosynthesis in plants, showing their role in coordinating these pathways for photosynthesis and thermotolerance.

A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3'-terminus untranslated region

This study identifies a highly attenuated SARS-CoV-2 related pangolin coronavirus variant with a 104nt deletion in the 3'-UTR HVR, showing reduced virulence in vitro and in vivo.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Evaluation of the anti-tumor activities of Sulfonylurea Derivatives

This study evaluates the anti-tumor activities of 25 sulfonylurea derivatives in breast carcinoma cell lines, finding concentration- and time-dependent inhibitory effects on cell growth, proliferation, migration, and survival.

Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

Molecular architecture and dynamics of SARS-CoV-2 envelope by integrative modeling

The paper models the SARS-CoV-2 envelope structure using an integrative multiscale approach, revealing dynamic behavior and molecular interactions of the M protein.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.