Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M. Kar, F. Dar, T. J. Welsh, L. Vogel, R. Kuhnemuth, A. Majumdar, G. Krainer, T. M. Franzmann, S. Alberti, C. A. M. Seidel, T. Knowles, A. A. Hyman, R. V. Pappu
This study investigates cluster formation in subsaturated solutions of RNA binding proteins with prion-like domains and finds that cluster formation and phase separation are coupled through sequence-specific interactions.
bioRxiv · Feb 3, 2022Biophysics