A. A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

The paper shows that glutamate reveals distinct energy and length scales for phase separation and clustering of FET family proteins in sub-saturated solutions.

The paper investigates how surface phase transitions control protein condensation to form tight junction belts through ZO-scaffold proteins and actin polymerization.

This study quantifies collective interactions in biomolecular phase separation by analyzing dilute phase concentrations and free energy, revealing how salts and small molecules modulate condensate formation.

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

The paper investigates how Ded1p translation factors assemble into condensates in response to heat across fungi, identifying structural and amino acid determinants of temperature sensitivity.

This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.

This study investigates cluster formation in subsaturated solutions of RNA binding proteins with prion-like domains and finds that cluster formation and phase separation are coupled through sequence-specific interactions.

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

The paper develops a physics-based theory for quantifying diffusive dynamics in liquid condensates and validates it using fluorescence recovery after photobleaching experiments.

The paper shows that proteins forming liquid condensates can reenter a phase-separated state at high salt concentrations due to hydrophobic and non-ionic interactions, distinct from low-salt electrostatic-driven phase separation.

The paper investigates how temperature changes affect P granule condensates in C. elegans, showing their reversible dissolution and recondensation, which can be modeled by thermodynamic equilibrium principles.

This paper introduces a label-free method to measure the composition of biomolecular condensates with many components, showing it can capture complex dynamics and stoichiometry without perturbing the system.

This study uses optical tweezers to observe Klf4 condensation on DNA, showing surface-mediated microphases that reconcile phase separation with nuclear organization.

This paper introduces a microdroplet platform to rapidly generate high-resolution phase diagrams of biomolecular condensates and demonstrates its application in studying phase transitions.

The paper identifies translation factories and co-translational RNA targeting through a dual protein/mRNA localization screen in human cells.

This study shows that PFK-1.1 dynamically forms liquid-like condensates in neurons under energy stress, revealing a new mechanism for subcellular organization.

The paper shows that phase separation can buffer gene expression noise by forming liquid droplets in mammalian cells, providing a fast mechanism for noise reduction.

This study shows tau forms distinct kinetic phases on microtubules that regulate kinesin motors and severing enzymes like katanin.

The paper identifies a novel pathway involving Rab5 and Alsin that regulates stress-activated cytoprotective signaling on mitochondria, linking mitochondrial stress response to ALS pathology.

The paper identifies PP2A and microtubule pulling forces as key factors in PCM disassembly during mitotic exit in C. elegans embryos.

The paper shows that tau forms liquid droplets that concentrate tubulin, enabling local microtubule bundle nucleation without centrosomes.