F. Dar

Biomolecular condensates form spatially inhomogeneous network fluids

This study uses multiple techniques to characterize the structural properties of biomolecular condensates, revealing network fluid behavior with spatial inhomogeneities.

Quantitative description of the phase separation behavior of the multivalent SLP65-CIN85 complex

The paper quantifies SH3-PRM interactions in SLP65/CIN85 complexes and models their phase separation behavior using LASSI, revealing an intramolecular interaction.

Crowder titrations enable the quantification of driving forces for macromolecular phase separation

This paper demonstrates how crowder titrations can quantify intrinsic driving forces for macromolecular phase separation by measuring saturation concentrations and second virial coefficients.

Dynamical control enables the formation of demixed biomolecular condensates

This study identifies dynamical control as a mechanism enabling the formation of demixed biomolecular condensates by showing that asynchronous molecular production is required for their coexistence.

Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

This study investigates cluster formation in subsaturated solutions of RNA binding proteins with prion-like domains and finds that cluster formation and phase separation are coupled through sequence-specific interactions.

Structure-function relationships in mitochondrial transcriptional condensates

This study reconstitutes mitochondrial transcriptional condensates in vitro and shows that RNA production alters their phase behavior and leads to non-equilibrium structures.

Ligand Effects on Phase Separation of Multivalent Macromolecules

This study uses theory and computation to show how ligands regulate scaffold phase behavior by binding to specific sites, affecting condensate stability and structure.

LASSI: A lattice model for simulating phase transitions of multivalent proteins

LASSI simulates phase transitions of multivalent proteins using a lattice model, generating insights into condensate formation and design.