7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
M. Brenner, C. Zink, L. Witzinger, A. Keller, K. Hadamek, S. Bothe, M. Neuenschwander, C. Villmann, J. P. von Kries, H. Schindelin, E. Jeanclos, A. Gohla
This study identifies 7,8-dihydroxyflavone as a direct inhibitor of pyridoxal phosphatase, increasing PLP levels in mouse hippocampal neurons and validating PDXP as a druggable target.
bioRxiv · Oct 4, 2023Biochemistry