Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model
C.-Y. Tsai, Y.-C. Chou, C.-Y. Chen, J.-T. Jan, M.-L. Chang, L.-A. Lu, P.-Y. Huang, M. F.- C. Chu, T.-T. Hsu, Y.-P. Hsueh
This study creates a human ACE2 transgenic mouse model to investigate sex-biased SARS-CoV-2 infection and brain cell susceptibility, finding higher mortality in males and altered neuronal responses to the virus.
bioRxiv · May 4, 2021 · PreprintMicrobiology