C.-Y. Chen

Microscale Spatial Dysbiosis in Oral biofilms Associated with Disease

The paper examines spatial bacterial arrangement in oral biofilms from healthy and diseased implants, finding that disease is associated with single-genus patches and proposing spatial structure as a biomarker for microbiome stability.

Redox control of the deubiquitinating enzyme Ubp2 regulates translation during stress

This study shows that Ubp2, a DUB, is redox-regulated during oxidative stress in yeast, controlling K63-ub chains on ribosomes and restoring translation post-stress.

Baseline microbiome composition impacts resilience to and recovery following antibiotics

This study investigates how baseline gut microbiome composition affects resilience to and recovery from antibiotic treatment, identifying key taxa and functional modules associated with resilience.

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.

The unseen invaders: tracking phylogeographic dynamics and genetic diversity of cryptic Pomacea canaliculata and P. maculata (Golden Apple Snails) across Taiwan

This study tracks the phylogeographic dynamics and genetic diversity of invasive golden apple snails in Taiwan to inform management strategies.

Histone acetyltransferase HAF2 associates with PDC to control H3K14ac and H3K23ac in ethylene response

This study identifies HAF2 as a histone acetyltransferase that interacts with EIN2-C and PDC to regulate H3K14ac and H3K23ac in response to ethylene.

Synthesis and Assembly of a New-generation Bifunctional Lipid Nanoparticle for Selective Delivery of mRNA to Antigen Presenting Cells

This paper develops a new mRNA-BLNP3 nanoparticle that selectively delivers mRNA to antigen-presenting cells, showing improved immune responses and reduced liver accumulation compared to previous versions.

Redox Active Plant Phenolic, Acetosyringone, for Electrogenetic Signaling

This paper demonstrates that acetosyringone, a plant phenolic, can induce gene expression in E. coli's OxyRS regulon when oxidized via electrode potential, expanding electronic control of microbial responses.

Mycorrhizal symbiont provides growth benefits in host plants via phosphate and phenylpropanoid metabolism

This study identifies a mycorrhizal fungus that promotes plant growth through phosphate solubilization and phenylpropanoid metabolism.

Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

This study identifies 4-dmH, a water-soluble heliomycin derivative, as more effective than parental heliomycin in oral cancer by targeting the tNOX-SIRT1 axis and inducing apoptosis.

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2 in vitro

This study identifies OPCs and punicalagin as potent inhibitors of SARS-CoV-2 infection, with punicalagin showing the strongest activity against omicron variants and viral entry.

Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis

This study shows that calpain-2 expression in glioblastoma cells reduces TMZ-induced DNA damage and p53-dependent apoptosis, leading to chemoresistance.

VPS13A and VPS13C influence lipid droplet abundance

This study shows that loss of VPS13A or VPS13C reduces lipid droplet abundance in cells under oleate-stimulated conditions.

The high diversity of Scedosporium and Lomentospora species and their prevalence in human-disturbed areas in Taiwan

This study identifies high prevalence of Scedosporium and Lomentospora species in urban and hospital soils in Taiwan, linked to human activities.

Insertion of YFP at P5CS1 and AFL1 shows the potential, and potential complications, of gene tagging for functional analyses of stress-related proteins

The paper uses gene tagging in Arabidopsis to study stress-related proteins, showing both its utility and potential to disrupt gene expression.

Fungal auxin is a quorum-based modulator of blast disease severity

This study identifies fungal auxin as a quorum-sensing signal modulating rice blast disease severity through IAA biosynthesis and secretion.

Spatial differences in stoichiometry of EGR phosphatase and Microtubule-Associated Stress Protein 1 control root meristem activity during drought stress.

The paper shows that spatial differences in EGR and MASP1 expression and phosphorylation control root meristem activity during drought stress.

Response of Endozoicomonas montiporae to heat stress and coral host lysates

This study investigates how E. montiporae responds to heat stress and coral host lysates by analyzing protein expression changes.

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage

This study quantifies how gut microbiota affects inflammation and organ damage in hypertension using germ-free and colonized mice, finding the kidney is more susceptible to microbial influence.

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model

This study creates a human ACE2 transgenic mouse model to investigate sex-biased SARS-CoV-2 infection and brain cell susceptibility, finding higher mortality in males and altered neuronal responses to the virus.

Combining an alarmin HMGN1 peptide with PD-L1 blockade facilitates stem-like CD8+ T cell expansion and results in robust antitumor effects

This study combines an HMGN1 peptide with PD-L1 blockade to expand stem-like CD8+ T cells and enhance antitumor effects in mouse models.

Noncanonical usage of stop codons in ciliates expands proteins with Q-rich motifs

The paper identifies Q-rich motifs in proteins across eukaryotes and shows their expansion in ciliates due to noncanonical stop codon usage, which may prevent triplet repeat disorders.

The histone deacetylase HDA15 interacts with MAC3A and MAC3B to regulate intron retention of ABA-responsive genes

The paper identifies HDA15's interaction with MAC3A and MAC3B in regulating ABA-responsive intron retention and histone acetylation levels.

Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051

This study reports the NMR structures of Shewanella woodyi H-NOX protein with and without IWP-051, revealing conformational changes and dynamic behavior in the binding pocket.

Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR

This study shows chronic palmitic acid exposure reduces AKT in beta-cells via mTOR activation, leading to cell cycle inhibition and T2D risk.

Plasticity in parental effects confers rapid larval thermal tolerance in Nematostella vectensis

The paper shows that parental exposure to heat increases larval thermal tolerance in Nematostella vectensis, with plasticity in this effect across populations.

Common properties of visually-guided saccadic behavior and bottom-up attention in marmoset, macaque, and human

This study compares saccadic behavior and bottom-up attention across marmoset, macaque, and human in free-viewing and visually-guided tasks, finding similar kinematics and saliency responses.

Circulating microRNA-762 upregulates colorectal cancer might through Wnt-1/b-catenin signaling

This study identifies miR-762 as a biomarker upregulating CRC growth and invasion via Wnt-β-catenin signaling in mice and human patients.

Crosskingdom growth benefits of fungus-derived phytohormones in Choy Sum

This study identifies fungus-derived phytohormones from Penicillium citrinum that promote Choy Sum growth through volatile metabolites and hormone-like compounds.

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

The paper investigates how a common SLC39A8 variant affects brain metal transport and plasma glycosylation in schizophrenia, identifying manganese-related changes and potential biomarkers.