Author

Y.-C. Chou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

J.-T. Jan· 3 shared C. Ma· 2 shared C.-P. Sun· 2 shared C.-Y. Tsai· 2 shared H.-C. Wu· 2 shared H.-H. Ma· 2 shared H.-T. Lin· 2 shared M. Kumari· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

J.-T. Jan

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

D.-C. Lee, J.-H. Tai, H.-F. Lin, T.-L. Chao, Y. Ruan, Y.-W. Cheng, Y.-C. Chou, Y.-Y. Lin, S.-Y. Chang, P.-J. Chen, S.-H. Yeh, H.-Y. Wang

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

bioRxiv · Feb 10, 2023Evolutionary Biology

Broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 derived from mRNA-lipid nanoparticle-immunized mice

R.-M. Lu, K.-H. Liang, H.-L. Chiang, F.-F. Hsu, H.-T. Lin, W.-Y. Chen, F.-Y. Ke, M. Kumari, Y.-C. Chou, H.-C. Wu

This paper develops broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 using mRNA-lipid nanoparticle immunization in mice, showing effectiveness against multiple variants.

bioRxiv · Apr 19, 2022Immunology

BMAL1 and MEX3A co-regulate intestinal stem cell succession

F.-P. Chang, C.-K. Wang, Y.-C. Chou, T.-J. Chen, Y.-W. Wu, S. Sridharan, P.-H. Hsu, W. W. Hwang-Verslues

This study identifies BMAL1 and MEX3A as regulators of intestinal stem cell succession and shows that timing chemotherapy can protect stem cells by modulating their circadian expression.

bioRxiv · Mar 8, 2022 · PreprintCell Biology

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

I.-J. Lee, C.-P. Sun, P.-Y. Wu, Y.-H. Lan, I.-H. Wang, W.-C. Liu, S.-C. Tseng, S.-I. Tsung, Y.-C. Chou, M. Kumari, Y.-W. Chang, H.-F. Chen, Y.-S. Lin, T. -Y. Chen, C.-W. Chiu, , M.-H. Tao

This study evaluates Omicron-specific mRNA vaccines and finds they induce strong neutralizing antibodies against Omicron but not other variants, while bivalent vaccines show broader neutralizing activity.

bioRxiv · Jan 31, 2022Microbiology

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

R. Kulkarni, W.-C. Chen, Y. Lee, C.-F. Kao, S.-L. Hu, H.-H. Ma, J.-T. Jan, C.-C. Liao, J.-J. Liang, H.-Y. Ko, C.-P. Sun, Y.-S. Lin, Y.-C. Wang, S.-C. Wei, Y.-L. Lin, , W. Chang

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

bioRxiv · Aug 3, 2021Immunology

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model

C.-Y. Tsai, Y.-C. Chou, C.-Y. Chen, J.-T. Jan, M.-L. Chang, L.-A. Lu, P.-Y. Huang, M. F.- C. Chu, T.-T. Hsu, Y.-P. Hsueh

This study creates a human ACE2 transgenic mouse model to investigate sex-biased SARS-CoV-2 infection and brain cell susceptibility, finding higher mortality in males and altered neuronal responses to the virus.

bioRxiv · May 4, 2021 · PreprintMicrobiology

Human Surfactant Protein D Binds S1 and Receptor Binding Domain of Spike protein and acts as an entry inhibitor of SARS-CoV-2 Pseudotyped viral particles in vitro

M.-H. Hsieh, N. Beirag, V. Murugaiah, Y.-C. Chou, W.-S. Kuo, H.-F. Kao, T. Madan, U. Kishore, J.-Y. Wang

This study shows that rfhSP-D binds SARS-CoV-2 S1 protein and inhibits viral entry into cells, suggesting its potential as an antiviral therapy.

bioRxiv · Dec 18, 2020Microbiology

A possible physical mechanism of the torque generation of the bacterial flagellar motor

Y.-c. Chou

The paper proposes a physical mechanism for torque generation in bacterial flagellar motors, showing it aligns with experimental observations and simulations.

bioRxiv · Jan 9, 2020 · PreprintBiophysics