Author

L.-F. Lye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:multiple species· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1

Frequent Co-Authors

S. M. Beverley· 3 shared A. Llanos Cuentas· 1 shared A. Shanmugasundram· 1 shared C. Hertz-Fowler· 1 shared C. Tomlinson· 1 shared D. E. Dobson· 1 shared E. A. Brettmann· 1 shared F. Silva-Franco· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

S. M. Beverley

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Parasite hybridization promotes spreading of endosymbiotic viruses

S. Heeren, I. Maes, M. Sanders, L.-F. Lye, J. Arevalo, A. Llanos Cuentas, L. Garcia, P. Lemey, S. M. Beverley, J. Cotton, J.-C. Dujardin, F. Van den Broeck

This study shows that parasite hybridization in cutaneous leishmaniasis increases the spread of endosymbiotic viruses, contributing to disease severity.

bioRxiv · Mar 24, 2023Evolutionary Biology

An RNA interference (RNAi) toolkit and its utility for functional genetic analysis of Leishmania ( Viannia )

L.-F. Lye, K. L. Owens, S. Jang, J. E. Marcus, E. A. Brettmann, S. M. Beverley

This study develops and applies RNAi tools to Leishmania (Viannia) species, showing that RNAi efficacy increases with stem length and enables hypomorphic analysis of essential genes.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites

W. C. Warren, N. Akopyants, D. E. Dobson, C. Hertz-Fowler, L.-F. Lye, P. J. Myler, G. Ramasamy, A. Shanmugasundram, F. Silva-Franco, S. Steinbiss, C. Tomlinson, R. K. Wilson, S. M. Beverley

The paper provides high-quality genome assemblies and gene annotations for 13 Leishmania and related species to study the origins of parasitism.

bioRxiv · May 29, 2021Microbiology