Pharmacology & ToxicologybioRxivPreprint
Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts
DOI 10.1101/2023.01.27.525941
Author
P. J. Myler
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 13 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship6 papers
Recent·Most cited
- BiochemistrybioRxiv
Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
A. Maker, M. Bolejack, L. Schecterson…·B. M. Gumbiner
The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.
- BiophysicsbioRxiv
Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody
B. Xie, A. Maker, A. V. Priest…·S. Sivasankar
This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.
DOI 10.1073/pnas.2204473119 - MicrobiologybioRxiv
Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites
W. C. Warren, N. Akopyants, D. E. Dobson…·S. M. Beverley
The paper provides high-quality genome assemblies and gene annotations for 13 Leishmania and related species to study the origins of parasitism.
DOI 10.1128/mra.00545-21 - Cell BiologybioRxivPreprint
A divergent protein kinase A in the human pathogen Leishmania is associated with cell cortex microtubules and controls cell shape
R. Fischer-Weinberger, S. Bachmaier, V. Ober…·D. Zilberstein
This paper identifies a novel PKA regulatory subunit in Leishmania that localizes to microtubules and controls promastigote shape by tethering the catalytic subunit to the cell cortex.
DOI 10.1101/2021.04.24.440790 - Cell BiologybioRxivPreprint
The hunger games: sensing host arginine is essential for Leishmania parasite virulence
A. Goldman Pinkovich, S. Kannan, R. Nitzan-Koren…·D. Zilberstein
This study shows that Leishmania parasites use an arginine sensing mechanism to enhance virulence by up-regulating arginine transport during infection.