L. Garcia

Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics

The paper introduces ccAFv2, a high-resolution cell cycle classifier for scRNA-seq data, which outperforms existing methods and classifies six cell cycle states and a quiescent-like G0 state.

Presence of Triatoma breyeri (Reduviidae, Triatominae) in Bolivia

The paper identifies Triatoma breyeri in Bolivia and suggests it was recently introduced through human activity, remaining confined to a specific dry valley region.

First concrete documentation for presence of Aedes (Stegomyia) albopictus in Bolivia: Dispelling previous anecdotes

This study confirms the presence of Aedes albopictus in Bolivia through larval sampling and morphological identification, marking the first concrete documentation of the species in the country.

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

Parasite hybridization promotes spreading of endosymbiotic viruses

This study shows that parasite hybridization in cutaneous leishmaniasis increases the spread of endosymbiotic viruses, contributing to disease severity.

Characterization of Three Variants of SARS-CoV-2 in vivo Shows Host-Dependent Pathogenicity in Hamsters

This study compares the pathogenicity of three SARS-CoV-2 variants in different animal models, showing host-dependent outcomes and the importance of model selection.

Internally-controlled and dynamic optical measures of functional tumor biology

This paper develops internally controlled optical reporters to quantitatively measure functional tumor biology, improving the accuracy of drug response assessment in vitro and in vivo.

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

On the origin and evolution of RNA editing in metazoans

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

Intermittent hormonal therapy shows similar outcome than SOC in ER+ breast cancer preclinical model.

This study shows intermittent hormonal therapy achieves similar tumor control as standard-of-care in ER+ breast cancer models with reduced drug use and preserved sensitive cell phenotypes.

Real Time PCR for the Evaluation of Treatment Response in Clinical Trials of Adult Chronic Chagas Disease: Usefulness of Serial Blood Sampling and qPCR Replicates.

This paper evaluates serial blood sampling and qPCR replicates to improve PCR sensitivity for detecting treatment response in Chagas disease trials.