L.-S. Bouchard

Global anti-tumor immunity after localized, bioengineered Treg depletion

This paper presents a biodegradable scaffold that locally depletes Tregs and activates T cells to clear solid tumors, inducing an immunological abscopal effect on distant tumors.

Augmentation of T-cell activation by oscillatory forces and engineered antigen-presenting cells

This study shows that oscillatory movement of engineered antigen-presenting cells enhances T-cell activation and expands regulatory T cells more effectively than static cultures.

T-cell activation is modulated by the 3D mechanical microenvironment

This study shows that T-cell activation increases in stiffer 3D hydrogels compared to softer ones, indicating mechanical sensing by T cells.