Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy
V. Bhatia, N. V. Kamat, T. E. Pariva, L.-T. Wu, A. Tsao, K. Sasaki, L. T. Wiest, A. Zhang, D. Rudoy, R. Gulati, R. A. Patel, M. P. Roudier, L. D. True, M. C. Haffner, P. S. Nelson, , J. K. Lee
This study develops STEAP1 CAR T cell therapy for advanced prostate cancer, showing potent antitumor activity and safety in preclinical models, but also identifies antigen loss as a resistance mechanism.
bioRxiv · May 16, 2022 · PreprintCancer Biology