V. Bhatia

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

Development of a robotic cluster for automated and scalable cell therapy manufacturing

This paper develops a robotic system to automate cell therapy manufacturing, demonstrating comparable results to manual methods in expanding human CD8+ T cells.

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations

This paper introduces a combinatorial genetic strategy to generate diverse cancer models and uses single-cell sequencing to identify polygenic drivers of cancer phenotypes.

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy

This study develops STEAP1 CAR T cell therapy for advanced prostate cancer, showing potent antitumor activity and safety in preclinical models, but also identifies antigen loss as a resistance mechanism.

PolyJet 3D Printing of Tissue Mimicking Materials: An Investigation of Characteristic Properties of 3D Printed Synthetic Tissue

This paper evaluates the mechanical and lubricity properties of new 3D printed synthetic tissue materials compared to biological tissues, finding they closely mimic porcine tissue characteristics and offer improved repeatability.

Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox 1 mediated prostate cancer progression.

The paper identifies a transcriptional network involving ERG, AR, and DLX1 in prostate cancer progression and shows BET inhibitors can target this network.

Polyjet 3D printing of tissue-mimicking materials: how well can 3D printed synthetic myocardium replicate mechanical properties of organic myocardium?

This study evaluates how well 3D printed Digital Anatomy myocardium replicates the mechanical properties of porcine myocardium in terms of compliance, puncture, suturing, and cutting performance.

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

This study shows that androgen deprivation therapy upregulates SPINK1, which enhances cellular plasticity and contributes to poor outcomes in prostate cancer.

Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer.

This study identifies miRNA-338-5p and miRNA-421 as epigenetically silenced in SPINK1-positive prostate cancer, and shows their restoration inhibits oncogenic properties.