Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver inflammation and hepatic fibrosis in mice
Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Simone Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian M. Kiessling, Thomas Clavel, Norbert Wagner, Angela Schippers
This study shows ICAM-1 protects against adipose tissue inflammation and insulin resistance but worsens liver inflammation and fibrosis in mice with diet-induced obesity.
bioRxiv · Apr 28, 2025 · PreprintImmunology