Author

Laura Kus

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Nathaniel HeintziD· 3 shared Thomas S. Carroll· 3 shared Christina PressliD· 2 shared David A. DavisiD· 2 shared Kärt MätlikiD· 2 shared Matthew BaffutoiD· 2 shared Matthew Robert PauliD· 2 shared Paul Darnell· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Nathaniel HeintzORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington's disease

Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Hasnahana Chetia, Maria Esterlita Siantoputri, Erika Sipos, Yurie Maeda, Paul Darnell, Nicholas Didkovsky, Laura Kus, Thomas S. Carroll, Douglas Barrows, Christina Pressl, Nathaniel Heintz

This study identifies epigenetic mechanisms linking cell type-specific enhancer activity to somatic CAG expansion and toxicity in Huntington's disease.

bioRxiv · May 21, 2025 · PreprintNeuroscience

Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum

Kärt Mätlik, Matthew Baffuto, Laura Kus, Amit Laxmikant Deshmukh, David A. Davis, Matthew Robert Paul, Thomas S. Carroll, Marie‐Christine Caron, Jean‐Yves Masson, Christopher E. Pearson, Nathaniel Heintz

The paper investigates CAG repeat expansions and their association with cell death in specific brain regions in Huntington's disease using molecular profiling.

Nature Genetics · Jan 30, 2024Peer-reviewedNeuroscience

Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington's Disease

Christina Pressl, Kärt Mätlik, Laura Kus, Paul Darnell, Ji‐Dung Luo, Matthew Robert Paul, Alison R. Weiss, William A. Liguore, Thomas S. Carroll, David A. Davis, Jodi L. McBride, Nathaniel Heintz

The paper identifies layer 5a corticostriatal neurons as selectively vulnerable in Huntington's disease using single nucleus RNA sequencing and shows they have extensive mHTT-CAG expansions.

Neuron · Jan 17, 2024Peer-reviewedNeuroscience