Author

Paul Darnell

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christina PressliD· 2 shared Laura Kus· 2 shared Nathaniel HeintziD· 2 shared Thomas S. Carroll· 2 shared Alison R. WeissiD· 1 shared David A. DavisiD· 1 shared Douglas BarrowsiD· 1 shared Erika Sipos· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Christina PresslORCID

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2 papers

Recent·Most cited

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington's disease

Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Hasnahana Chetia, Maria Esterlita Siantoputri, Erika Sipos, Yurie Maeda, Paul Darnell, Nicholas Didkovsky, Laura Kus, Thomas S. Carroll, Douglas Barrows, Christina Pressl, Nathaniel Heintz

This study identifies epigenetic mechanisms linking cell type-specific enhancer activity to somatic CAG expansion and toxicity in Huntington's disease.

bioRxiv · May 21, 2025 · PreprintNeuroscience

Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington's Disease

Christina Pressl, Kärt Mätlik, Laura Kus, Paul Darnell, Ji‐Dung Luo, Matthew Robert Paul, Alison R. Weiss, William A. Liguore, Thomas S. Carroll, David A. Davis, Jodi L. McBride, Nathaniel Heintz

The paper identifies layer 5a corticostriatal neurons as selectively vulnerable in Huntington's disease using single nucleus RNA sequencing and shows they have extensive mHTT-CAG expansions.

Neuron · Jan 17, 2024Peer-reviewedNeuroscience