Author

LeYuan Gu

Zhejiang Chinese Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Honghai ZhangiD· 8 shared HaiXiang Ma· 6 shared XiTing Lian· 6 shared Yuling WangiD· 6 shared WeiHui ShaoiD· 5 shared JiaXuan Gu· 4 shared YaXuan WuiD· 4 shared Yu QianiD· 4 shared

Activity by Year

2020-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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8 shared papersNeuroscience

Honghai ZhangORCID

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8 papers

Recent·Most cited

Locus Coeruleus to Medial Prefrontal Cortex Noradrenergic Neural Circuit Modulates States of Consciousness during Sevoflurane Anesthesia in Mice

WeiHui Shao, Yue Yang, YaXuan Wu, XuanYi Di, ZiWen Zhang, Lu Liu, LeYuan Gu, Xiaoxia Xu, ZhuoYue Zhang, JiaXuan Gu, Honghai Zhang

This study investigates how sevoflurane anesthesia affects consciousness by examining the role of locus coeruleus to medial prefrontal cortex noradrenergic circuits in mice.

bioRxiv · May 1, 2025 · PreprintNeuroscience

NE contribution to rebooting unconsciousness caused by midazolam

LeYuan Gu, WeiHui Shao, Lu Liu, Qing Yan Xu, Yuling Wang, JiaXuan Gu, Yue Yang, ZhuoYue Zhang, YaXuan Wu, Yue Shen, Yu Qian, XiTing Lian, HaiXiang Ma, Yuanli Zhang, Honghai Zhang

This study identifies the role of the LC-VLPO noradrenergic circuit and GABAA-R in midazolam-induced unconsciousness and its recovery.

eLife · Nov 20, 2024Peer-reviewedNeuroscience

Modulation Of SUDEP By Central Serotonergic Cooperating with Noradrenergic Circuits: A Synergistic-Dependent Manner

Qing Xu, Xiaoxia Xu, YaXuan Wu, Yue Yang, LeYuan Gu, ZhuoYue Zhang, ZiWen Zhang, XuanYi Di, Yuling Wang, Yu Qian, XiTing Lian, HaiXiang Ma, Honghai Zhang

The paper investigates the synergistic role of central serotonergic and noradrenergic circuits in modulating SUDEP through experimental methods and identifies a potential therapeutic target.

bioRxiv · Jul 20, 2024 · PreprintNeuroscience

Restoring the loss of consciousness under sevoflurane anesthesia in states of anxiety and depression by potently activating serotonergic pathways in brain

Yuling Wang, Yue Yang, YaXuan Wu, Xiaoxia Xu, WeiHui Shao, Shuai Li, Qing Xu, LeYuan Gu, Lu Liu, ZiWen Zhang, XuanYi Di, Hui Wu, DanDan Yan, Yue Shen, XinZhong Chen, Honghai Zhang

This study identifies a serotonergic pathway between the central amygdala and medial prefrontal cortex that accelerates sevoflurane anesthesia recovery, particularly in individuals with anxiety and depression.

bioRxiv · Jun 19, 2024 · PreprintNeuroscience

The Serotonergic Neural Circuit Between The Dorsal Raphe Nucleus And The Basolateral Amygdala Is Implicated In Modulating The Arousal from Sevoflurane Anesthesia

Yu Qian, LeYuan Gu, XiTing Lian, Yuling Wang, Qing Yang Xu, HaiXiang Ma, Lu Liu, WeiHui Shao, JiaXuan Gu, Yue Liang Shen, Lihai Chen, Honghai Zhang

bioRxiv · Oct 12, 2022 · PreprintNeuroscience

The 5-hydroxytryptaminergic Neurons Locating in the Dorsal Raphe Nucleus and Different Receptors of 5-HT Were Implicated in Mediating the Arousal from Sevoflurane Anesthesia

HaiXiang Ma, LeYuan Gu, Yuling Wang, Qing Yang Xu, Yu Qian, XiTing Lian, WeiHui Shao, Lu Liu, JiaXuan Gu, Yue Liang Shen, Honghai Zhang

The study investigates the role of 5-HT neurons and their receptors in mediating delayed awakening from sevoflurane anesthesia in mice.

bioRxiv · May 22, 2022 · PreprintNeuroscience

The Interaction Between The Noradrenergic Neurons In The Locus Coeruleus And Beta-1 Adrenergic Receptor (β1-AR) In The Cardiomyocytes Was Implicated In Modulating SUDEP

XiTing Lian, Yu Qian, HaiXiang Ma, LeYuan Gu, Qing Yan Xu, Yuling Wang, Yue Liang Shen, Honghai Zhang

This study investigates the role of noradrenergic neurons in the locus coeruleus and β1-AR in cardiomyocytes in modulating SUDEP through respiratory and cardiac arrhythmias.

bioRxiv · Jan 10, 2022 · PreprintNeuroscience

Optogenetic activation of the serotonergic neural circuit between dorsal raphe nucleus and the pre-Bötzinger complex contributes to inhibition of the seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model

HaiXiang Ma, Yu Qian, Yue Liang Shen, XiTing Lian, LeYuan Gu, Lu Han, Haiting Zhao, Chang Zeng, Kazuki Nagayasu, Honghai Zhang

bioRxiv · Dec 4, 2020 · PreprintNeuroscience