Li Huang

In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion

This paper presents a drug repurposing framework using in vivo transcriptomics to expand indications by matching drug signatures with disease signatures, successfully recovering established uses of semaglutide and proposing new ones.

A pretrained unified model enables cellular functional profile prediction and multi-objective virtual drug screening

InsilicoCell predicts cellular functional profiles and enables multi-objective virtual drug screening by integrating diverse molecular data and tasks.

Rhizoxin and 2,4-diacetylphloroglucinol Contribute to Biocontrol of Pseudomonas protegens Pf-5 Against Pea Ascochyta Blight Pathogen Didymella pinodes

Fruit trichome density outweighs cuticle thickness as the dominant barrier to postharvest water loss in tomato

This study shows that fruit trichome density is a more significant factor than cuticle thickness in determining postharvest water loss in tomatoes, as mutants with fewer trichomes had reduced water loss and longer shelf life despite thinner cuticles.

SERPINA3 and NDRG1 are critical diagnostic immune genes associated with macrophages in preeclampsia

This study identifies SERPINA3 and NDRG1 as critical immune genes associated with M2 macrophages in preeclampsia using machine learning and experimental validation.

Direct effector recognition by a tandem kinase triggers non-canonical immunity in wheat

The paper identifies a wheat resistance gene Lr41 that directly recognizes an effector AvrLr41 through its pseudokinase domain, revealing a non-canonical immune mechanism involving kinase-type receptors and helper proteins.

Beyond commensalism: Genomic insights into micrococcin P1-producing Staphylococcus chromogenes

This study identifies MP1-producing S. chromogenes strains with antimicrobial activity and low virulence, suggesting their role as protective commensals in dairy ruminants.

Efficient Hydrophilic Small Molecule Delivery To Retinal Cell Lines Using Solid Lipid Nanoparticle Containing Gel Core

This study develops a solid lipid nanoparticle formulation for efficient delivery of hydrophilic drugs to retinal cells, showing improved encapsulation efficiency and cellular uptake.

Multiple antibodies identify glypican-1 associated with exosomes from pancreatic cancer cells and serum from patients with pancreatic cancer

The paper confirms Glypican-1 enrichment on pancreatic cancer exosomes using multiple antibodies and demonstrates specific detection in patient serum.

N-BLR, a primate-specific non-coding transcript, modulates the epithelial-to-mesenchymal transition and leads to colorectal cancer invasion and migration

The paper identifies N-BLR, a primate-specific non-coding RNA, as a regulator of epithelial-to-mesenchymal transition and colorectal cancer invasion and migration.