Raghu Kalluri

The paper reproduces and validates a previously reported model of TGF-β2-induced EndMT through Smad-dependent and independent pathways across multiple studies and laboratories.

This study shows engineered extracellular vesicles delivering BACE1-targeting siRNA reduce amyloid beta plaques in a mouse model of Alzheimer's disease.

VrySure is an AI platform that detects manipulated and AI-generated biomedical images using multiple modules, achieving higher accuracy in some tasks compared to existing tools.

This study compares Akt signaling induced by Tumstatin and Endostatin in human endothelial cells, finding Tumstatin reduces Akt phosphorylation while Endostatin does not affect Akt activation.

This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.

This study identifies small molecule Kras inhibitors that synergize with anti-CTLA4 therapy to reprogram Tregs and enhance immunotherapy efficacy in PDAC.

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

This paper develops a machine learning method to identify cancer exosomes using a proteomic signature, achieving high accuracy across multiple biological fluids.

The paper identifies structural differences in zebrafish α4 chain of type IV collagen and shows its conserved anti-angiogenic activity compared to humans.

The paper confirms Glypican-1 enrichment on pancreatic cancer exosomes using multiple antibodies and demonstrates specific detection in patient serum.