Li Sun

Pediatric brain charts reveal ADHD biotypes with distinct developmental, molecular, and therapeutic profiles

The paper identifies two distinct ADHD biotypes using brain imaging and transcriptomic data, showing different developmental, molecular, and treatment responses.

Ligand-specific endothelial Notch signaling coordinates brain pericyte specification and expansion

This study identifies ligand-specific endothelial Notch signaling as a mechanism coordinating brain pericyte specification and expansion in zebrafish.

Protection and deprotection of the Rec8 cohesin complex during meiosis

The paper investigates the protection of Rec8 cohesin during meiosis II by analyzing the roles of Sgo1 and Moa1 in fission yeast.

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure Sequelae

This study shows that inhibiting MAGL in astrocytes reduces seizures and neuroinflammation by activating CB1-PPAR-γ signaling, preserving synaptic function and preventing cognitive decline in epilepsy.

Architectural Confinement and Seasonal Forcing Shape Cross-Domain Pathogen Assemblages in Complex Built Environments

This study investigates how spatial and seasonal factors shape airborne pathogen communities in built environments over a year.

Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation

This study shows that Sgo1 inhibits APC/C to prevent separase activation during mitosis but enhances Rec8 cohesin protection during meiosis through its D-box.

A human gut-BBB-brain microphysiological model for studying neurodegenerative diseases

This paper develops a human gut-BBB-brain microphysiological model to study neurodegenerative diseases and finds that gut-brain interactions can promote brain organoid maturation and recapitulate AD pathology.

Selective Inactivation of Astrocytic Monoacylglycerol Lipase for Alzheimer Disease Therapy

This study identifies astrocytic monoacylglycerol lipase (MAGL) as a therapeutic target for Alzheimer's disease, showing that its inactivation reduces pathology and improves cognition in transgenic mice.

A diverse population of pericoerulear neurons controls arousal and exploratory behaviors

The paper identifies diverse GABAergic neurons in the locus coeruleus (LC) dendritic field that modulate arousal and behaviors through transcriptional, spatial, and functional diversity.

SNX-2112 inhibits the ERBB3high tumor population in Plexiform Neurofibromas

This study shows SNX-2112 inhibits ERBB3high tumor cells in Plexiform Neurofibromas, reducing viability and downstream signaling in vitro and demonstrating in vivo efficacy.

Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

The paper identifies two liver cancer subtypes using multi-omics data, develops a prognostic model with superior accuracy, and validates findings through single-cell analysis.

Creating Red Light-Controlled Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity

The paper introduces a method to create red light-controlled protein dimerization systems with high specificity for optogenetic applications.

Mutation rate estimation for 15 autosomal STR loci in a large population from Mainland China

This study estimates mutation rates for 15 autosomal STR loci in a large Chinese population and finds higher paternal mutation rates and correlations with age and geographic location.