A structure-based epitope tagging approach identifies vulnerable sites on the malarial P36-P52 protein complex for antibody-mediated neutralization of Plasmodium sporozoites
Samhita Das, Lien Boeykens, Manon Loubens, Carine Marinach, Sylvie Briquet, Line De Vocht, Isabel Pintelon, Jean-Pierre Timmermans, Yann G.‐J. Sterckx, Olivier Silvie
The paper identifies vulnerable sites on the P36-P52 protein complex of Plasmodium sporozoites using structural biology and functional assays, showing that antibodies targeting these sites can neutralize SPZ invasion.
PLoS Pathogens · Jul 8, 2026Peer-reviewedMicrobiology