Yann G.‐J. Sterckx

This study identifies the CD2 intracellular domain of PCDH15 as an intrinsically disordered polymer with biophysical properties relevant to auditory mechanotransduction.

The paper shows that LiTat 1.3, a key VSG for diagnosing T. b. gambiense, forms homotrimers in solution, not homodimers, using structural and biophysical methods.

This study investigates how Mer2 recruits Spp1 to form complexes involved in meiotic DSB machinery through structural and biochemical analysis.

This paper identifies a camelid single-domain antibody that inhibits T. brucei enolase and elucidates its inhibitory mechanism using biochemical, biophysical, and structural methods.

The paper identifies vulnerable sites on the P36-P52 protein complex of Plasmodium sporozoites using structural biology and functional assays, showing that antibodies targeting these sites can neutralize SPZ invasion.

This study shows that CLIP is essential for host cell invasion by both merozoites and sporozoites of P. berghei, supporting a conserved role of the CLAMP-CLIP-SPATR complex in apicomplexan invasion.

This study identifies a camelid single-domain antibody that allosterically inhibits trypanosomatid pyruvate kinases, reducing parasite growth.

This study investigates the role of intrinsic disorder in invariant surface glycoproteins (ISGs) of African trypanosomes, showing they can switch between compact and elongated conformers to balance immune evasion and host interaction.

The paper presents AlphaFold structures of Rec114-Mei4 and Mer2 complexes, showing their conserved structure across eukaryotes and DNA-binding properties.