Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape
Lele Song, Qinglan Li, Lingbo Xia, Arushi Sahay, Qi Qiu, Y. Li, Haitao Li, Kotaro Sasaki, Katalin Suszták, Hao Wu, Liling Wan
This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.
Nature Communications · Jul 15, 2024Peer-reviewedCancer Biology