Author

Lingyi Wang

5Department of Developmental Biology and Cancer, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Adam TurňaiD· 2 shared David O’ConnoriD· 2 shared Jonas DemeulemeesteriD· 2 shared Marc R. MansouriD· 2 shared Tanya Rapoz-D’SilvaiD· 2 shared Adele K. FieldingiD· 1 shared Alejandro GutierreziD· 1 shared Alfred Thomas LookiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Adam TurňaORCID

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2 papers

Recent·Most cited

MYC-induced oncogenesis is dependent on acidic patches within its N-terminal intrinsically disordered domain.

Víctor Llombart, David O’Connor, Jonas Demeulemeester, Amandeep Bhamra, Silvia Šurinová, Adam Turňa, Kent T.M. Fung, Lingyi Wang, Yang Li, Tanya Rapoz-D’Silva, Farah Ahmed, Henri Niskanen, Ida Stöppelkamp, Denes Hnisz, Sandro Bottaro, , Marc R. Mansour

This study identifies acidic patches in the MYC N-terminal disordered domain essential for oncogenesis and chromatin interaction, offering new therapeutic targets.

bioRxiv · Jun 16, 2025 · PreprintCancer Biology

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

Sunniyat Rahman, Gianna Bloye, Nadine Farah, Jonas Demeulemeester, Joana R. Costa, David O’Connor, Rachael Pocock, Tanya Rapoz-D’Silva, Adam Turna, Lingyi Wang, SooWah Lee, Adele K. Fielding, Juliette Roels, Roman Jaksik, Małgorzata Dawidowska, , Marc R. Mansour

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

bioRxiv · Feb 6, 2024Cancer Biology