Alejandro Gutiérrez

This study identifies CHKA's role in alkylating agent resistance through lipid droplet-mediated regulation of RAD51 transcription in T-ALL.

This study identifies tRNA-Arg-TCT-4-1 as a new anti-cancer therapeutic target and shows that targeting it with an ASO suppresses tumorigenesis and extends survival in mouse models.

This study shows that ADAT2/3-mediated tRNA editing supports cancer cell growth and tumorigenicity by enhancing translation of growth-promoting mRNAs.

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

HCR-FlowFISH identifies cis-regulatory elements and their target genes by quantifying gene expression changes after CRISPR perturbations, using >270,000 perturbations to detect CREs for multiple genes.