Author

Joana R. Costa

University College LondonORCID 0000-0002-6225-1011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Marc R. MansouriD· 2 shared Adam TurňaiD· 1 shared Adele Kay FieldingiD· 1 shared Alejandro GutiérreziD· 1 shared Boon Haow ChuaiD· 1 shared Chai Yeen Goh· 1 shared David O’ConnoriD· 1 shared Dennis KappeiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Marc R. MansourORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 24, 2025

The TARZN complex binds de novo enhancer mutations and promotes oncogenic expression in T-ALL

Nurkaiyisah Zaal Anuar, Chai Yeen Goh, Boon Haow Chua…·Dennis Kappei

The paper identifies the TARZN complex, which binds de novo enhancer mutations and promotes TAL1 overexpression in T-ALL through RNA methylation.

DOI 10.1101/2025.01.24.634708

humanproteomics

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Cancer BiologyBloodPeer-reviewedSep 24, 2024

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

Sunniyat Rahman, Gianna Bloye, Nadine Farah…·Marc R. Mansour

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

10 citations

humanDNA methylation

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