Author

Lisa Dwane

Wellcome Sanger Institute

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Molecular Biology· 1

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

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Alexandra BeckiD· 1 shared Andrew Roger BassettiD· 1 shared Ching Chiek KohiD· 1 shared Emanuel GonçalvesiD· 1 shared Emily Souster· 1 shared Emre KarakoçiD· 1 shared Inigo Barrio‐HernandeziD· 1 shared Lykourgos‐Panagiotis ZalmasiD· 1 shared

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1 shared paperMolecular Biology

Alexandra BeckORCID

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1 paper

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedDec 6, 2025

Genetic interaction library screening with a next-generation dual guide CRISPR system

Thomas Burgold, Emre Karakoç, Emanuel Gonçalves…·Andrew Roger Bassett

The paper introduces a next-generation dual guide CRISPR system for efficient genetic interaction screening, achieving low undesired guide pairs and balanced expression, and demonstrates its application in colorectal cancer cells.

14 citationstop 5%

humanCRISPR screen

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