Cell BiologybioRxivPreprint
The Greatwall/PP2A-B55α axis remodels the G2/M boundary and shapes cellular dependence on PKMYT1
Róbert Zach, Alex Herbert, Calin-Mihai Dragoi…·Helfrid Hochegger
The paper investigates how perturbations of the CDK1-Greatwall-PP2A-B55 feedback loop affect cell-cycle control in different cell types, finding that PP2A-B55 acts as a context-dependent G2/M repressor and that cancer cells show specific sensitivities to PKMYT1 inhibitors.
DOI 10.64898/2026.09.04.749407