Author

Lorenzo Scutteri

École Polytechnique Fédérale de Lausanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:protein design· 3 Assay:protein structure· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:yeast· 2 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1

Frequent Co-Authors

Patrick BarthiD· 3 shared Sahand Jamal RahiiD· 3 shared Andreas MöglichiD· 1 shared Aysima HacisuleymaniD· 1 shared Damien ThéveniniD· 1 shared Florence PojeriD· 1 shared Julie V. NguyeniD· 1 shared Kelvin LauiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

Patrick BarthORCID

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Author profile →

4 papers

Recent·Most cited

Light-directed evolution of dynamic, multi-state, and computational protein functionalities

Vojislav Gligorovski, Marco Labagnara, Lorenzo Scutteri, Marius Blackholm, Andreas Möglich, Nahal Mansouri, Sahand Jamal Rahi

This paper introduces optovolution, a directed evolution method using light and cell cycle oscillations to evolve dynamic protein functionalities, and demonstrates its application in yeast.

Cell · Mar 1, 2026Peer-reviewedSynthetic Biology

Deep learning-based joint sequence-structure de novo membrane protein design

Lucas S. P. Rudden, Remo Bättig, Vinnie Andrews, Julie V. Nguyen, Martin Stoll, Lorenzo Scutteri, Michal Winnicki, Melissa Joy Call, Matthew Edwin Call, Damien Thévenin, Patrick Barth

This paper introduces TMDiffusion, a deep learning model for designing membrane proteins, achieving high experimental success and accurate structural predictions.

bioRxiv · Aug 15, 2025 · PreprintBiophysics

De novo design of light-regulated dynamic proteins using deep learning

Lorenzo Scutteri, Luciano A. Abriata, S. Zhang, Aysima Hacisuleyman, Kelvin Lau, Florence Pojer, Sahand Jamal Rahi, P. Barth

This paper designs light-regulated dynamic proteins using deep learning, showing precise optogenetic control of cellular processes.

bioRxiv · Aug 12, 2025 · PreprintBiophysics

Minimal integrating shuttle vectors for Saccharomyces cerevisiae depleted of restriction sites outside the polylinker region

Lorenzo Scutteri, Patrick Barth, Sahand Jamal Rahi

The paper designs and validates six minimal integrating shuttle vectors for Saccharomyces cerevisiae with reduced size and restriction sites outside the MCS.

bioRxiv · Nov 5, 2024 · PreprintSynthetic Biology