Lucas S. P. Rudden

This paper introduces TMDiffusion, a deep learning model for designing membrane proteins, achieving high experimental success and accurate structural predictions.

This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.