Metformin Stabilizes the Abdominal Aorta in Aneurysm by Restoring VSMC Mitochondrial Homeostasis via the AMPK-SIRT1-PGC-1α Axis
Baoyu Gao, Yuehuan Zeng, Lu Ye, Xinyu Yuan, Dongping Yang, Shaojun Lin, Jun Zhou, Buwen Liang, Yaliang Jie, Suping Ding, Jiahe Xie, Zhidong Yuan
This study shows metformin prevents abdominal aortic aneurysm by restoring vascular smooth muscle cell mitochondrial function through the AMPK-SIRT1-PGC-1α pathway.
bioRxiv · Mar 2, 2026 · PreprintCell Biology