Jun Zhou

The OxyR-Responsive TacAT Module Promotes Oxidative Stress Adaptation and In Vivo Fitness in K. pneumoniae

This study identifies the OxyR-TacAT regulatory module in K. pneumoniae, showing it enhances peroxide tolerance and in vivo fitness by regulating stress-response genes.

Homeostatic control of stem cell activity during intestinal regeneration.

This study identifies NF-Y and Nej as a negative feedback module that regulates intestinal stem cell proliferation and prevents hyperproliferation during homeostasis and disease.

Spacing effect improves generalization in biological and artificial systems

This study introduces a bio-inspired spacing effect into neural networks and validates it in Drosophila, showing improved generalization through spaced intervals and innate variations.

Metformin Stabilizes the Abdominal Aorta in Aneurysm by Restoring VSMC Mitochondrial Homeostasis via the AMPK-SIRT1-PGC-1α Axis

This study shows metformin prevents abdominal aortic aneurysm by restoring vascular smooth muscle cell mitochondrial function through the AMPK-SIRT1-PGC-1α pathway.

A zebrafish immunodeficiency model induced by the combination of Tacrolimus and Everolimus for rapid assessment of immune-enhancing agents

The paper establishes a zebrafish immunodeficiency model using Tacrolimus and Everolimus to rapidly assess immune-enhancing agents over 5 days.

Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of complex traits in pig.

The paper performs a multi-breed meta-GWAS in pigs to identify genomic regions associated with complex traits and integrates with PigGTEx to prioritize variant-gene-tissue-trait circuits.

Single-turnover kinetic analysis of non-LTR retrotransposition defines the mechanism and rate constants governing each step

This study defines the kinetic mechanism and rate constants for non-LTR retrotransposition using single-turnover analysis, revealing the complete reaction sequence and second-strand synthesis.

Genome-wide methylation profiling identify hypermethylated HOXL subclass genes as potential markers for esophageal squamous cell carcinoma detection

The paper identifies hypermethylated HOXL subclass genes as potential methylation markers for detecting esophageal squamous cell carcinoma and other cancers.