Cell BiologybioRxivPreprint
Metformin Stabilizes the Abdominal Aorta in Aneurysm by Restoring VSMC Mitochondrial Homeostasis via the AMPK-SIRT1-PGC-1α Axis
Baoyu Gao, Yuehuan Zeng, Lu Ye…·Zhidong Yuan
This study shows metformin prevents abdominal aortic aneurysm by restoring vascular smooth muscle cell mitochondrial function through the AMPK-SIRT1-PGC-1α pathway.
DOI 10.64898/2026.02.27.708352