Depletion of astrocyte inflammatory pathway in the arcuate nucleus of the hypothalamus is sufficient to prevent the diet-induced metabolic alterations of polygenically predisposed obese rats
Anaïs Bouchat, Luca Papini, Janine Schlaepfer, Patricia Kulka, Christelle Le Foll
This study shows that reducing astrocyte inflammation in the hypothalamus prevents obesity in genetically predisposed rats but not once obesity has developed.
bioRxiv · Mar 30, 2026 · PreprintPhysiology