DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma
Tao Lin, Chenjun Huang, Chenhao Tong, Heng liu, Roman Liebe, Lungen Lu, Jun Li, Jonathan A. Lindquist, Matthias ebert, Peter Mertens, Steven Dooley, Honglei Weng
The paper identifies a YB-1-mA-DNMT regulatory axis that drives cisplatin resistance in iCCA by promoting ABCB1 expression through promoter demethylation.
bioRxiv · Jun 7, 2026 · PreprintMolecular Biology