Roman Liebe

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

The paper identifies a YB-1-mA-DNMT regulatory axis that drives cisplatin resistance in iCCA by promoting ABCB1 expression through promoter demethylation.

This study identifies TGF-β as a key regulator of liver progenitor cell quiescence and activation, showing its dual role in inhibiting proliferation while being counteracted by HGF and EGF signals.

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.

This study shows that rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice by blocking RNA Pol II activity in pre-loaded pro-inflammatory genes.