Intraperitoneal programming of tailored CAR macrophages via mRNA-LNP to boost cancer immunotherapy
Kedan Gu, Ting Liang, Luting Hu, Yifan Zhao, Weiyang Ying, Mengke Zhang, Yashuang Chen, Benmeng Liang, Xinrui Lin, Yanqi Zhang, Hongyu Wu, Meng Wang, Yuping Zhu, Wenxi Wang, Y. Zhang, , Weihong Tan
This study develops an mRNA-LNP delivery system to program CAR-Ms in vivo, showing enhanced antitumor effects through immune activation and synergy with PD-1/L1 therapy.
Nature Communications · Dec 24, 2025Peer-reviewedBioengineering